Dimethylformamide → HCID 19696319, compound

HRID 863702Notes

Reaction equation

HRID 863702 reaction equation
[C:1]([CH:3]1[CH2:32][CH2:31][N:6]2[C:7]3[C:12]([C:13]([C:14]4[C:15](=[O:30])[O:16][C:17](=O)[C:18]=4[C:19]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[N:21]([CH3:28])[CH:20]=4)=[C:5]2[CH2:4]1)=[CH:11][CH:10]=[CH:9][CH:8]=3)#[N:2].C[N:34](C)C=O>N>[C:1]([CH:3]1[CH2:32][CH2:31][N:6]2[C:7]3[C:12]([C:13]([C:14]4[C:15](=[O:30])[NH:34][C:17](=[O:16])[C:18]=4[C:19]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[N:21]([CH3:28])[CH:20]=4)=[C:5]2[CH2:4]1)=[CH:11][CH:10]=[CH:9][CH:8]=3)#[N:2]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 19696340HCID 19696340, compound

Product 1

HCID 19696319HCID 19696319, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of 400 mg of 3-[8-cyano-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)furan-2,5-dione in 12 ml of dimethylformamide and 12 ml of 33% aqueous ammonia was heated to 140° C. for 3 hours. The mixture was cooled and the resulting solid was filtered off and dried to give 275 mg of 3-[8-cyano-6,7,8,9-tetrahydropyrido-[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 312°-313° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationthe resulting solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-3c48912eb90249e3897ce081cd042806
Source dataset
uspto-grants-1998_02
Patent number
US05721245

Reaction notes

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