Hydrochloric Acid → 2-Chloro-1-(pyridin-3-yl)ethan-1-one--hydrogen chloride (1/1)

To a solution of 12 g (11 mL, 100 mmol) of 3-acetylpyridine in 100 mL of ethyl ether was added 100 mL of 1 M ethereal hydrogen chloride. The resultant precipitate was filtered and 15.0 g (95.2 mmol) was collected and placed in a 500-mL round bottom flask equipped with a magnetic stir bar. To this was added 95 mL of 1 M hydrogen chloride in acetic acid. After the mixture was stirred until all the solid had dissolved, 12.7 g (95.2 mmol) of N-chlorosuccinimide (NCS) was added in one portion. The solution turned yellow and the NCS gradually dissolved. After 4 h, a white precipitate had formed. The mixture was allowed to stir for 2.5 days. It was then filtered. The solid collected was washed with 10 mL of acetic acid and 200 mL of ethyl ether to give 15.2 g (83%) of the title compound as a white solid: 1H NMR (200 MHz, d6 -DMSO) δ9.22 (t, H, J=1 Hz), 8.29 (dd, 1H, J=1.6, 5.1 Hz), 8.55 (td, 1H, J=2, 8.1 Hz), 7.82 (ddd, 1H, J=0.8, 5.1, 8.1 Hz), 5.27 (s, 2H).

1. filtrationThe resultant precipitate was filtered
2. custom15.0 g (95.2 mmol) was collected
3. customplaced in a 500-mL round bottom flask
4. customequipped with a magnetic stir bar
5. additionTo this was added 95 mL of 1 M hydrogen chloride in acetic acid
6. dissolutionhad dissolved
7. customa white precipitate had formed
8. stirringto stir for 2.5 days
9. filtrationIt was then filtered
10. customThe solid collected
11. washwas washed with 10 mL of acetic acid and 200 mL of ethyl ether

ORD record

ord-d0c53c45cae84a85ab1293c41927d577

Source dataset

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05561142