反应详情

To a solution of 1-iodo-3-(2-phenylethoxy)propane (0.566 g; 1.95 mmol) in dry THF (9 ml) is added 2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride (0.59 g; 1.9 mmol). NaH (78 mg; 1.9 mmol) is then added at room temperature. The reaction mixture is heated at reflux for 30 minutes, then cooled, concentrated in vacuo, and the residue column chromatographed with 10% MeOH/CH2Cl2The product is dissolved in EtOH acidified with HCl/EtOH concentrated to a solid and recrystallized from CH2Cl2 /petroleum ether to obtain N-[2-(4-(benzoxazol-2-yl)benzyloxy)ethyl]-3-(2-phenylethoxy)propanamine hydrochloride. (m.p. 134°-135° C.).

1. temperatureThe reaction mixture is heated
2. temperatureat reflux for 30 minutes
3. temperaturecooled
4. concentrationconcentrated in vacuo
5. customthe residue column chromatographed with 10% MeOH/CH2Cl2The product
6. dissolutionis dissolved in EtOH
7. concentrationconcentrated to a solid
8. customrecrystallized from CH2Cl2 /petroleum ether