1,1'-Carbonyldiimidazole → HCID 489428, compound

HRID 864436Notes

Reaction equation

HRID 864436 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([C:18]([OH:20])=O)=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:21]([NH:23][C:24]1[C:25]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[N:26][CH:27]=[CH:28][CH:29]=1)[CH3:22].C(N1C=CN=C1)(N1C=CN=C1)=O>C1COCC1>[CH3:22][CH2:21][NH:23][C:24]1[CH:29]=[CH:28][CH:27]=[N:26][C:25]=1[N:30]1[CH2:35][CH2:34][N:33]([C:18]([C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:10][C:11]=3[CH:12]=2)=[O:20])[CH2:32][CH2:31]1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 811465-(phenylmethoxy)-1H-indole-2-carboxylic acidHCID 10130476N-Ethyl-2-(piperazin-1-yl)pyridin-3-amine

Product 1

HCID 489428HCID 489428, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the general procedure of EXAMPLE 16 and making non-critical variations but starting with 5-benzyloxyindole-2-carboxylic acid (1.0 g), 1-(3-ethylamino-2-pyridinyl)piperazine (International Publication WO 87/01706, 0.81 g), 1,1'-carbonyldiimidazole (0.61 g) and THF (7 ml), the title compound is obtained, mp 192°-193°.

Sources & evidence

ORD record
ord-cc3f875efa74499482b6451af8092944
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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