1-(4-Pyridyl)piperazine → HCID 18918575, compound

HRID 864799Notes

Reaction equation

HRID 864799 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[N:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>CO>[N:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:2]3[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=3)[CH2:21][CH2:22]2)=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 792226-Chloronicotinic acid

Product 1

HCID 18918575HCID 18918575, compoundYield 43.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
220 °C

Procedure

A mixture of 6-chloronicotinic acid (3.21 g) and 1-(4-pyridyl) piperazine (3.32 g) was heated to 220° C. for 3 minutes. The mixture was cooled and methanol (10 ml)was added. The resulting suspension was boiled for 10 minutes, cooled and filtered to give 6-[4-(4-pyridyl)piperazin-1-yl]nicotinic acid (2.51 g) which was used without further purification.

Workup

  1. temperatureThe mixture was cooled
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-7412f3a2890443d8b7fc215e9aca06ab
Source dataset
uspto-grants-1996_10
Patent number
US05563141

Reaction notes

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