Trifluoroacetic acid → 2,8-Dimethyl-4-naphthalen-2-yl-1,2,3,4-tetrahydroisoquinoline

HRID 86549Notes

Reaction equation

HRID 86549 reaction equation
[CH3:1][N:2]([CH2:3][CH:4]([OH:5])[c:6]1[cH:7][c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2[cH:14][cH:15]1)[CH2:16][c:17]1[c:18]([CH3:23])[cH:19][cH:20][cH:21][cH:22]1.[F:24][C:25]([F:26])([F:27])[C:28]([O:29][C:30](=[O:31])[C:32]([F:33])([F:34])[F:35])=[O:36].[OH:37][C:38]([C:39]([F:40])([F:41])[F:42])=[O:43]>>[CH3:1][N:2]1[CH2:3][CH:4]([c:6]2[cH:7][c:8]3[cH:9][cH:10][cH:11][cH:12][c:13]3[cH:14][cH:15]2)[c:22]2[c:17]([c:18]([CH3:23])[cH:19][cH:20][cH:21]2)[CH2:16]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 9845Trifluoroacetic anhydrideHCID 689975302-[Methyl-(2-methyl-benzyl)-amino]-1-naphthalen-2-yl-ethanol

Product 1

HCID 689976452,8-Dimethyl-4-naphthalen-2-yl-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-2a88f24fd4b449b5b7e17890dd8a7764
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…