HCID 10717394, compound → HCID 10568249, compound

HRID 865503Notes

Reaction equation

HRID 865503 reaction equation
C(OC([NH:8][CH:9]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])=[O:11])=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][CH:9]([CH2:21][C:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[NH:24][CH:23]=1)[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])=[O:11]

Participants

3

Reactant 1

HCID 10717394HCID 10717394, compound

Product 1

HCID 10568249HCID 10568249, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A stirring solution of 2-t-butoxycarbonylamino-3-(1H-indol-3-yl)-N-(2-chlorobenzyl)propanamide (6.00 g, 14 mmol) in 30 ml of 70% aqueous trifluoroacetic acid (21 ml trifluoroacetic acid, 9 ml water) was allowed to stir overnight at room temperature. The progress of this deprotection reaction was monitored by thin layer chromatography.

Workup

  1. customThe progress of this deprotection reaction

Sources & evidence

ORD record
ord-fb76ecefa60b42558d815dea2563f087
Source dataset
uspto-grants-1996_10
Patent number
US05565568

Reaction notes

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