Methylamine → HCID 19963160, compound

HRID 865915Notes

Reaction equation

HRID 865915 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].[CH3:23][NH2:24]>C(O)C>[CH3:23][NH:24][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 21849844HCID 21849844, compound

Product 1

HCID 19963160HCID 19963160, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

After repetition of the previous steps, a mixture of 7-chloro-4-(3'-methylanilino)-6-nitroquinazoline (10.5 g), an ethanolic solution of methylamine (30% weight/volume; 100 ml) and ethanol (100 ml) was stirred at ambient temperature for 16 hours. The mixture was evaporated to give 7-methylamino-4-(3'-methylanilino)-6-nitroquinazoline which was used without further purification.

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-be840b94b3cb41d78632752614fbfae4
Source dataset
uspto-grants-1996_10
Patent number
US05569658

Reaction notes

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