Tetrahydrofuran → 2-tert-Butyl-1-[(4,4-difluorocyclohexyl)methyl]-N-methyl-1H-benzimidazol-5-amine
Reaction equation
[Al+3:29].[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([n:9]1[CH2:10][CH:11]1[CH2:12][CH2:13][C:14]([F:17])([F:18])[CH2:15][CH2:16]1)[cH:19][cH:20][c:21]([NH:23][C:24](=[O:25])[O:26][CH3:27])[cH:22]2.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[H-:28].[H-:31].[H-:32].[H-:33].[Li+:30]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[n:6][c:7]2[c:8]([n:9]1[CH2:10][CH:11]1[CH2:12][CH2:13][C:14]([F:17])([F:18])[CH2:15][CH2:16]1)[cH:19][cH:20][c:21]([NH:23][CH3:24])[cH:22]2Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-bde65c787d9b44e5953758db347b8391
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…