Iodoethane → HCID 21468880, compound

HRID 866260Notes

Reaction equation

HRID 866260 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)#[N:2].[CH2:18]([Mg]Br)[CH3:19].C(I)C>C1COCC1>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][CH3:19])#[N:2]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 21468934HCID 21468934, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 21468880HCID 21468880, compoundYield 31.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(2-cyanophenyl)indole (1.26 mmoles,630 mg) was dissolved in THF (20 ml) and treated with ethylmagnesium bromide (1.26 mmoles, 0.630 ml) and ethyl iodide (3.45 mmoles, 0.54 g) as in Example 24 to yield 98 mg of 5-(2-cyanophenyl)-3-ethylindole. (MS)

Sources & evidence

ORD record
ord-0efa76354d3544bd9eadf3b7a90ca8f3
Source dataset
uspto-grants-1996_10
Patent number
US05569768

Reaction notes

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