Cyanogen Bromide → 4-METHYL-PIPERAZINE-1-CARBONITRILE

HRID 866335Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[N:8]#[C:9]Br.[OH-].[Na+]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:9]#[N:8])[CH2:4][CH2:3]1

Participants

Reactant 3

HCID 10476Cyanogen Bromide

HCID 14798Sodium Hydroxide

HCID 531671-Methylpiperazine

Product 1

HCID 104191834-METHYL-PIPERAZINE-1-CARBONITRILE

Procedure

In the manner given in Example 1, N-methylpiperazine is treated with cyanogen bromide and aqueous sodium hydroxide to give 4-methyl-1-piperazinecarbonitrile.

Sources & evidence

ORD record: ord-60421e53c55e4d9583bbf1b39cf49d92
Source dataset: uspto-grants-1978_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04098791

Reaction notes

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