Formaldehyde → HCID 54405233, compound

HRID 866362Notes

Reaction equation

HRID 866362 reaction equation
[NH2:1][C:2]([P:8]([OH:11])(=[O:10])[OH:9])([P:4]([OH:7])(=[O:6])[OH:5])[CH3:3].C=O.P(Cl)(Cl)Cl>>[P:4]([CH:2]=[N:1][C:2]([P:4]([OH:7])(=[O:5])[OH:6])([P:8]([OH:11])(=[O:9])[OH:10])[CH3:3])([OH:7])([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 24387Phosphorus trichlorideHCID 84770(1-Aminoethylidene)bisphosphonic acid

Product 1

HCID 54405233HCID 54405233, compound

Procedure

103 g. of 1-amino ethane-1,1-diphosphonic acid are suspended in 100 g. of a 30% formaldehyde solution. 85 cc. of phosphorus trichloride are added thereto drop by drop while stirring. After the addition is completed, the mixture is heated to boiling until a homogeneous mixture is formed. The water is removed by evaporation in a vacuum. The resulting phosphonic acid mixture is precipitated by the addition of acetone. N-phosphono methylene-1-amino ethane-1,1-diphosphonic acid is obtained in this manner.

Workup

  1. additionAfter the addition
  2. temperaturethe mixture is heated
  3. customis formed
  4. customThe water is removed by evaporation in a vacuum
  5. customThe resulting phosphonic acid mixture is precipitated by the addition of acetone

Sources & evidence

ORD record
ord-1424e06f291248e488103bc1c490419e
Source dataset
uspto-grants-1978_07
Patent number
US04098814

Reaction notes

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