Pyridine → HCID 12398505, compound

HRID 866385Notes

Reaction equation

HRID 866385 reaction equation
Cl[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3].[CH3:18][CH:19]([OH:21])[CH3:20].N1C=CC=CC=1.C1(C)C(C)=CC=CC=1>O>[CH:19]([O:21][C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3])([CH3:20])[CH3:18]

Participants

6

Reactant 4

HCID 1049PyridineHCID 3776IsopropanolHCID 7237O-XyleneHCID 37664104-Benzyloxybenzoylchloride

Product 1

HCID 12398505HCID 12398505, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-chlorocarbonylphenoxy phenyl methane (12.3g.; 0.05 mole), propan-2-ol (3.6g.; 0.6 mole), pyridine (5g) and xylene (50ml) were boiled under reflux for 18hr. The cooled mixture was poured into water and extracted with dichloromethane. The organic extract was washed well with water and dried (anhyd. MgSO4), filtration and evaporation yielded 4-isopropoxycarbonylphenoxy phenyl methane, m.p. 62°-3° C.

Workup

  1. temperatureunder reflux for 18hr
  2. extractionextracted with dichloromethane
  3. extractionThe organic extract
  4. washwas washed well with water
  5. customdried
  6. filtration(anhyd. MgSO4), filtration and evaporation

Sources & evidence

ORD record
ord-1f39a5065dbd4048918838554cbb8f9d
Source dataset
uspto-grants-1978_07
Patent number
US04098816

Reaction notes

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