Water → alpha-Hydroxy[2-(beta,beta,beta-trichloroethoxycarbonyl)aminothiazol-4-yl]acetonitrile

HRID 866436Notes

Reaction equation

HRID 866436 reaction equation
[Cl:1][C:2]([Cl:16])([Cl:15])[CH2:3][O:4][C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=1)=[O:6].OP([O-])(O)=O.[K+].O.[C-:24]#[N:25].[K+]>CN(C)C=O>[OH:14][CH:13]([C:11]1[N:12]=[C:8]([NH:7][C:5]([O:4][CH2:3][C:2]([Cl:1])([Cl:15])[Cl:16])=[O:6])[S:9][CH:10]=1)[C:24]#[N:25]

Participants

6

Reactant 4

HCID 962WaterHCID 9032Potassium CyanideHCID 516951Monobasic potassium phosphateHCID 127632072-(beta,beta,beta-Trichloroethoxycarbonyl)amino-4-formylthiazole

Product 1

HCID 15137534alpha-Hydroxy[2-(beta,beta,beta-trichloroethoxycarbonyl)aminothiazol-4-yl]acetonitrile

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a mixture of 1.0 g. of 2-(β,β,β-trichloroethoxycarbonyl)amino-4-formylthiazole, 0.87 g. of KH2PO4, 6 ml. of water and 4 ml. of dimethylformamide is added 0.33 g. of KCN at room temperature and the mixture is stirred for 30 minutes. The reaction mixture is extracted with ethyl acetate and the ethyl acetate layer is washed with water and dried. Evaporation of ethyl acetate gives α-hydroxy-[2-(β,β,β-trichloroethoxycarbonyl)aminothiazol-4-yl]-acetonitrile 1.127 g.

Workup

  1. additionTo a mixture of 1.0 g
  2. extractionThe reaction mixture is extracted with ethyl acetate
  3. washthe ethyl acetate layer is washed with water
  4. customdried
  5. customEvaporation of ethyl acetate

Sources & evidence

ORD record
ord-8a90cc63c1364b6e8d0b7c0f087b0172
Source dataset
uspto-grants-1978_07
Patent number
US04098888

Reaction notes

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