反应详情

p-Nitrobenzyl glycinate hydrobromide (2.91 g., 10mMol) is suspended in H2O (5 ml.) and layered with EtOAc (15 ml.) The mixture is cooled in ice and stirred while ice-cold, saturated aqueous K2CO3 (2.5 ml.) is added. The layers are separated and the aqueous portion is extracted with more EtOAc (3 × 5 ml.). The combined EtOAc solution is washed with H2O and brine, dried with Na2SO4, filtered, and evaporated in vacuo to an off-white solid (1.81 g.). Recrystallization from Et2O yields p-nitrobenzyl glycinate as small, off-white needles.

1. temperatureis cooled in ice
2. additionis added
3. customThe layers are separated
4. extractionthe aqueous portion is extracted with more EtOAc (3 × 5 ml.)
5. washThe combined EtOAc solution is washed with H2O and brine
6. dry with materialdried with Na2SO4
7. filtrationfiltered
8. customevaporated in vacuo to an off-white solid (1.81 g.)
9. customRecrystallization from Et2O