Water → HCID 22762753, compound

HRID 866852Notes

Reaction equation

HRID 866852 reaction equation
Cl[CH2:2][C:3]1[O:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[C:15]1(=[O:25])[NH:19][C:18](=[O:20])[C:17]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]12.[K].O>CN(C)C=O>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[O:4][C:3]([CH2:2][N:19]3[C:18](=[O:20])[C:17]4=[CH:21][CH:22]=[CH:23][CH:24]=[C:16]4[C:15]3=[O:25])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7369662-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazoleHCID 24194345Phthalimide potassium salt

Product 1

HCID 22762753HCID 22762753, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A suspension of 2.3 g of 2-chloromethyl-5-(4-chlorophenyl) oxazole and 1.94 g of potassium phthalimide in 15 ml of dimethylformamide was stirred at room temperature for one hour. The reaction mixture was poured into 300 ml of water, and the resultant precipitate was filtered and recrystallized from ethanol to give 2.4 g (71 percent) of N-[5-(4-chlorophenyl)-2-oxazolyl]methylphthalimide.

Workup

  1. filtrationthe resultant precipitate was filtered
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-2c11c45f037d45448040d4a98aeb33bb
Source dataset
uspto-grants-1978_07
Patent number
US04101660

Reaction notes

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