Chlorotrimethylsilane → HCID 22750285, compound

HRID 866984Notes

Reaction equation

HRID 866984 reaction equation
[CH3:1][NH:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:13][C:14](=[O:21])[C:15](=[CH:19][CH:20]=2)[C:16](O)=O)=[CH:8][CH:7]=1)(=[O:5])=[O:4].O1CCCC1.C[Si]([Cl:31])(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[CH3:1][NH:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[NH:13][C:14](=[O:21])[C:15](=[CH:19][CH:20]=2)[CH2:16][Cl:31])=[CH:8][CH:7]=1)(=[O:5])=[O:4]

Participants

6

Reactant 4

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 22750313HCID 22750313, compound

Product 1

HCID 22750285HCID 22750285, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 5.0 g. of 6-[4-(methylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 250 ml. of tetrahydrofuran, 2.26 ml. of triethylamine, 2.05 ml. of trimethylsilyl chloride and 2.33 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(methylaminosulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-a7a698b5abfb4c489ea9df86ef4fb42a
Source dataset
uspto-grants-1978_07
Patent number
US04101661

Reaction notes

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