反应详情

温度

-10 °C

The amide (0.79 g) of Example 21 was added to a mixture of dimethyl formamide (100 ml) and thionyl chloride (2.0 ml) at -10° C., and stirred at -10° C. for 2 hrs. The mixture was poured on to ice-water and the precipitated product filtered off and washed with water, recrystallised from dimethylformamide, and dried at 155° C./15 mm. Hg, m.p. 290° C. (decomposes).

1. filtrationthe precipitated product filtered off
2. washwashed with water
3. customrecrystallised from dimethylformamide
4. customdried at 155° C./15 mm. Hg, m.p. 290° C. (decomposes)