Piperidine → HCID 178499397, compound

HRID 867258Notes

Reaction equation

HRID 867258 reaction equation
C1CCNCC1.COC(=O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>CS(C)=O.Cc1cccc(C)c1NC(=O)C(=O)O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>COC(=O)CC1CCc2cc(N3CCCCC3)cc3[nH]c(=O)c(=O)n1c23

Participants

7

Reactant 2

HCID 8082PiperidineHCID 10066635Methyl 2-(9-bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[1,2,3-de]quinoxalin-5-yl)acetate

Product 1

HCID 178499397HCID 178499397, compoundYield 30%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 149878692-(2,6-Dimethylphenylamino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-ff7a068e31cf4af1a1410cca4024bc84
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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