Water → 3-(1-(4-(3-(piperidin-1-yl)propoxy)-2,3-difluorophenyl)-1H-tetrazol-5-yl)-5-(1-isopentyl-1H-pyrazol-4-yl)pyridin-2-amine
Reaction equation
[Br:1][CH:2]([CH2:3][CH2:4][O:5][c:6]1[c:7]([F:35])[c:8]([F:34])[c:9](-[n:12]2[n:13][n:14][n:15][c:16]2-[c:17]2[c:18]([NH2:33])[n:19][cH:20][c:21](-[c:23]3[cH:24][n:25][n:26]([CH2:28][CH2:29][CH:30]([CH3:31])[CH3:32])[cH:27]3)[cH:22]2)[cH:10][cH:11]1)[CH3:36].[CH2:37]1[CH2:38][CH2:39][NH:40][CH2:41][CH2:42]1.[CH2:85]1[O:86][CH2:87][CH2:88][CH2:89]1.[O:44]1[CH2:45][CH2:46][N:47]([CH2:48][CH2:49][CH2:50][CH2:51][O:52][c:53]2[cH:54][cH:55][c:56](-[n:57]3[c:58](-[c:59]4[c:60]([NH2:61])[n:62][cH:63][c:64](-[c:65]5[cH:66][n:67][n:68]([CH2:69][CH2:70][CH:71]([CH3:72])[CH3:73])[cH:74]5)[cH:75]4)[n:76][n:77][n:78]3)[c:79]([F:80])[c:81]2[F:82])[CH2:83][CH2:84]1.[OH2:43]>>[CH2:2]([CH2:3][CH2:4][O:5][c:6]1[c:7]([F:35])[c:8]([F:34])[c:9](-[n:12]2[n:13][n:14][n:15][c:16]2-[c:17]2[c:18]([NH2:33])[n:19][cH:20][c:21](-[c:23]3[cH:24][n:25][n:26]([CH2:28][CH2:29][CH:30]([CH3:31])[CH3:32])[cH:27]3)[cH:22]2)[cH:10][cH:11]1)[N:40]1[CH2:39][CH2:38][CH2:37][CH2:42][CH2:41]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-72328b395ac6402e9b0facd5da0e734c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
Loading…