Piperidine → HCID 178519854, compound

HRID 867262Notes

Reaction equation

HRID 867262 reaction equation
C1CCNCC1.O=C(c1c[nH]c2ccc(Br)cc12)[C@H]1CCCN1C(=O)OCc1ccccc1>CS(C)=O.Cc1cccc(C)c1NC(=O)C(=O)O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>O=C(c1c[nH]c2ccc(N3CCCCC3)cc12)[C@H]1CCCN1C(=O)OCc1ccccc1

Participants

7

Reactant 2

HCID 8082PiperidineHCID 11224090Phenylmethyl (2R)-2-((5-bromo-1H-indol-3-yl)carbonyl)-1-pyrrolidinecarboxylate

Product 1

HCID 178519854HCID 178519854, compoundYield 1.38%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 149878692-(2,6-Dimethylphenylamino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-2dde4fbb8ce04bc181a682a7557abc71
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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