Piperidine → HCID 178519214, compound

HRID 867271Notes

Reaction equation

HRID 867271 reaction equation
C1CCNCC1.O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(I)c(F)c1>CS(C)=O.Cc1cccc(C)c1NC(=O)C(=O)O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>O=C1O[C@@H](Cn2ccnn2)CN1c1ccc(N2CCCCC2)c(F)c1

Participants

7

Reactant 2

HCID 8082PiperidineHCID 11257720(R)-5-((1H-1,2,3-Triazol-1-yl)methyl)-3-(3-fluoro-4-iodophenyl)oxazolidin-2-one

Product 1

HCID 178519214HCID 178519214, compoundYield 39.96%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 149878692-(2,6-Dimethylphenylamino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-a997bf0c4472451b8322e07f319ce5b0
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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