Piperidine → HCID 178462863, compound

HRID 867287Notes

Reaction equation

HRID 867287 reaction equation
C1CCNCC1.CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(Br)c2)n(CCO)c1=O>COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CCn1c(=O)c2c(nc(N[C@@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(N3CCCCC3)c2)n(CCO)c1=O

Participants

7

Reactant 2

HCID 8082PiperidineHCID 9871410Dasantafil

Product 1

HCID 178462863HCID 178462863, compoundYield 32.472%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-1e9819fc13134d6388708454c61c4d78
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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