Piperidine → HCID 178517240, compound

HRID 867292Notes

Reaction equation

HRID 867292 reaction equation
C1CCNCC1.O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1>COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>O=C1Nc2ccc(N3CCCCC3)cc2C(C#CC2CC2)(C(F)(F)F)O1

Participants

7

Reactant 2

HCID 8082PiperidineHCID 64139Efavirenz

Product 1

HCID 178517240HCID 178517240, compoundYield 0%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-44f82dbcbc8f4edb962d35d4d12e7ecb
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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