Piperidine → HCID 178500184, compound

HRID 867293Notes

Reaction equation

HRID 867293 reaction equation
C1CCNCC1.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1>COc1cccc(OC)c1NC(=O)C(=O)O.CS(C)=O.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(N2CCCCC2)cc1

Participants

7

Reactant 2

HCID 8082PiperidineHCID 15225389Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate

Product 1

HCID 178500184HCID 178500184, compoundYield 0%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 1188645032-((2,6-Dimethoxyphenyl)amino)-2-oxoacetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-5876661e31e24b0c816e513c647ba7d3
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

Loading…