Piperidine → HCID 178470271, Verbindung

HRID 867295Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 867295
C1CCNCC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Br)ccc1-2>CS(C)=O.O=C(O)C(=O)Nc1c(F)cccc1F.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N3CCCCC3)ccc1-2

Komponenten

7

Edukt 2

HCID 8082PiperidineHCID 10737466Ethyl 8-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate

Produkt 1

HCID 178470271HCID 178470271, VerbindungAusbeute 49,28 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 62657Potassium Phosphate, TribasicReagenzHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)KatalysatorHCID 28710784[(2,6-Difluorophenyl)carbamoyl]formic acidKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Aufarbeitung

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Quellen und Nachweise

ORD-Eintrag
ord-75be42c3f9fc406a8c61cdd44bcd8ec9
Quelldatensatz
Figure 4 from Chemistry informer libraries
Originallink
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