Piperidine → HCID 178470271, compound

HRID 867295Notes

Reaction equation

HRID 867295 reaction equation
C1CCNCC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Br)ccc1-2>CS(C)=O.O=C(O)C(=O)Nc1c(F)cccc1F.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N3CCCCC3)ccc1-2

Participants

7

Reactant 2

HCID 8082PiperidineHCID 10737466Ethyl 8-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate

Product 1

HCID 178470271HCID 178470271, compoundYield 49.28%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 28710784[(2,6-Difluorophenyl)carbamoyl]formic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-75be42c3f9fc406a8c61cdd44bcd8ec9
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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