Piperidine → HCID 178523006, compound

HRID 867339Notes

Reaction equation

HRID 867339 reaction equation
C1CCNCC1.O=C(NCc1ccc(F)cc1)c1nc(Br)c2cccnc2c1O>CS(C)=O.O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>O=C(NCc1ccc(F)cc1)c1nc(N2CCCCC2)c2cccnc2c1O

Participants

7

Reactant 2

HCID 8082PiperidineHCID 223464015-bromo-N-(4-fluorobenzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamide

Product 1

HCID 178523006HCID 178523006, compoundYield 0%

Reagents, catalysts & solvents 4

HCID 62657Potassium Phosphate, TribasicReagentHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)CatalystHCID 1188645142-[3,5-Bis(trifluoromethyl)anilino]-2-oxo-acetic acidCatalystHCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

Sources & evidence

ORD record
ord-2ecbbbb182354f8c9c95ea76b66d6ff2
Source dataset
Figure 4 from Chemistry informer libraries
Original link
View source

Reaction notes

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