Hydrochloric Acid → HCID 21289657, compound

HRID 867373Notes

Reaction equation

HRID 867373 reaction equation
[ClH:1].[CH3:2][N:3]([C:8]1[S:9][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[N:16]=2)=[N:11][N:12]=1)[C:4]([NH:6][CH3:7])=[O:5]>C(Cl)(Cl)Cl.C(OCC)C>[ClH:1].[CH3:2][N:3]([C:8]1[S:9][C:10]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[N:16]=2)=[N:11][N:12]=1)[C:4]([NH:6][CH3:7])=[O:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21289658HCID 21289658, compound

Product 1

HCID 21289657HCID 21289657, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

Dry hydrogen chloride gas was slowly bubbled into a stirred solution of 3.0grams (0.012 mol) of N,N'-dimethyl-N-[ 5-([6-fluorpyridin-2-yl]methyl]thio-1,3,4-thiadiazol-2-yl] urea (prepared by the method of Example 2) dissolved in a mixture of 50 ml of chloroform and 10 ml of diethyl ether over a 5 minute period at room temperature. Theprecipitated solid product was collected by vacuum filtration and dried to yield 3.3 grams of the title compound, m.p. 177°-179° C.

Workup

  1. customprepared by the method of Example 2)
  2. filtrationTheprecipitated solid product was collected by vacuum filtration
  3. customdried

Sources & evidence

ORD record
ord-9025a6b7f76e49eca675006f7d068f90
Source dataset
uspto-grants-1988_10
Patent number
US04775408

Reaction notes

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