反应详情

In a mixed solution consisting of 50 ml of DMSO and 30 ml of THF were dissolved 3.64 g (20 mmole) of 2-benzylglycerin and 9.26 g (48 mmole) of octyl bromide, and 8.96 g (160 mmole) of powdered potassium hydroxide was added to the solution, followed by vigorous stirring. Two hours later, the reaction solution was poured in cold water, and the mixture was extracted with n-hexane. The extract was washed with water, dried and concentrated, followed by purification by silica-gel chromatography (eluent: n-hexane-ethyl acetate, 20:1) to give 6.22 g (77%) of the desired compound as colorless liquid.

1. additionwas added to the solution
2. extractionthe mixture was extracted with n-hexane
3. washThe extract was washed with water
4. customdried
5. concentrationconcentrated
6. customfollowed by purification by silica-gel chromatography (eluent: n-hexane-ethyl acetate, 20:1)