Potassium Carbonate → 3-{3-[2-(4-Propyl-piperidin-1-yl)-ethoxy]-phenyl}-thieno[2,3-d]isoxazole

HRID 8679Notes

Reaction equation

HRID 8679 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:11]2[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[O:13][N:12]=2)[CH:8]=[CH:9][CH:10]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:25][CH2:26][CH2:27][CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>C(#N)C>[CH2:27]([CH:28]1[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][O:4][C:5]2[CH:6]=[C:7]([C:11]3[C:15]4[S:16][CH:17]=[CH:18][C:14]=4[O:13][N:12]=3)[CH:8]=[CH:9][CH:10]=2)[CH2:30][CH2:29]1)[CH2:26][CH3:25]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 311694-PropylpiperidineHCID 219835823-[3-(2-Bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

Product 1

HCID 219835623-{3-[2-(4-Propyl-piperidin-1-yl)-ethoxy]-phenyl}-thieno[2,3-d]isoxazole

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 4-N-propylpiperidine and acetonitrile essentially as described above in example 40. Purity by LC/MS (APCI)=96%, [M+H]+=371.

Sources & evidence

ORD record
ord-00713097cc4a4a48b60bcfb12597d27b
Source dataset
uspto-grants-2006_08
Patent number
US07091199B1

Reaction notes

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