反应详情

A solution of D-2 (304 mg), carbon tetrachloride (0.19 ml, 2 mmole), triphenylphosphine (524 mg), and TEA (0.28 ml) in dry THF (5 ml) is stirred under argon for 4 days. The reaction mixture is diluted with hexane (5 ml), filtered through a short silica column (elution with ethyl acetate/hexane, 1:1), and the filtrate concentrated. Chromatography of the residue on silica gel (elution with hexane/ethylacetate, 2:1) delivers D-3 as a solid.

1. filtrationfiltered through a short silica column (elution with ethyl acetate/hexane, 1:1)
2. concentrationthe filtrate concentrated