Potassium Carbonate → HCID 86742492, compound

HRID 868507Notes

Reaction equation

HRID 868507 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[O:6][CH2:7][CH2:8]Cl)([O-:3])=[O:2].[NH2:14][CH2:15][CH2:16][C:17]([N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[S:23][CH2:22][CH:21]=[CH:20]1)=[O:18].[C:30](=[O:33])([O-:32])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[O:6][CH2:7][CH2:8][NH:14][CH2:15][CH2:16][C:17]([N:19]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[S:23][CH2:22][CH2:21][CH2:20]1)=[O:18])([O-:3])=[O:2].[C:5]([O-:18])(=[O:6])/[CH:10]=[CH:11]/[C:30]([O-:32])=[O:33]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 43624871-(2-chloroethoxy)-2-nitrobenzeneHCID 21287188HCID 21287188, compound

Product 1

HCID 86742492HCID 86742492, compoundYield 55.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2-Nitrophenoxyethylchloride (0.26 g), 5-(3-Amino-propionyl)-1,5-benzothiazepine (0.355 g) and potassium carbonate (0.210 g) in toluene (15 ml) was refluxed for 16 hours. After cooling, objective compound (0.184 g) was obtained according to the method of experimental 1. m.p. 178°-180° C.

Workup

  1. temperaturewas refluxed for 16 hours
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-45b8551da0944f52ba6ba44b007c0cc5
Source dataset
uspto-grants-1988_10
Patent number
US04780462

Reaction notes

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