Dichloromethane → HCID 131715734, compound

HRID 868556Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]2[C:28](=O)[CH2:27][C:22]3([CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:21][CH:20]2[OH:30])[CH2:11][CH2:10]1.FC(F)(F)C(O)=[O:34].C(Cl)[Cl:39]>>[OH2:2].[ClH:39].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]2[CH2:28][CH2:27][C:22]3([CH2:23][CH2:24][CH2:25][CH2:26]3)[CH2:21][C:20]2=[O:30])[CH2:11][CH2:10]1.[OH2:34].[OH2:2].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]2[CH2:28][CH2:27][C:22]3([CH2:23][CH2:24][CH2:25][CH2:26]3)[CH2:21][C:20]2=[O:30])[CH2:11][CH2:10]1.[ClH:39]

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 14280606HCID 14280606, compound

Product 1

HCID 131715734HCID 131715734, compound

Procedure

To a solution prepared from 8-[3-[4-(2-methoxyphenyl)1-piperazinyl]propyloxy]-7-hydroxy-8-azaspiro[4.5]decan-9-one, 60 ml of CH2Cl2 and 30 ml of trifluoroacetic acid was added triethylsilylane (1.26 ml) in one portion. The mixture was stirred at room temperature for 1.5 hours.

Workup

additionwas added triethylsilylane (1.26 ml) in one portion

Sources & evidence

ORD record: ord-950e23a7c307482bb79ff9aa83b8037d
Source dataset: uspto-grants-1988_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04780466

Reaction notes

Loading…