反应详情

温度

90 °C

A suspension of 2.94 g of isatin, 4.20 g of 2-diisopropylaminoethyl chloride hydrochloride, and 3.17 g of anhydrous potassium carbonate in 50 ml of toluene was stirred for 4 hours at 90° C. After cooling, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane to obtain 4.93 g of 1-(2-diisopropylaminoethyl)isatin. The chemical properties of this product are identical with those of the product obtained by Reference Example 1.

1. temperatureAfter cooling
2. washthe reaction mixture was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated under reduced pressure
5. customThe residue was recrystallized from hexane