反应详情

温度

120 °C

A suspension of 1.10 g of (E)-1-(2-diisopropylaminoethyl)isatin 3-semicarbazone and 0.29 g of isopentylamine in a mixture of 150 ml of dry toluene and 20 ml of dry N,N-dimethylformamide was stirred for 23 hours at 120° C. The reaction mixture was concentrated under reduced pressure, and the residue was dissolved in dichloromethane. The solution was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified with silica gel flash column chromatography (eluent: chloroform) to obtain 1.12 g of (Z)-1-(2-diisopropylaminoethyl)isatin 3-(4-isopentylsemicarbazone) in a viscous oil.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. dissolutionthe residue was dissolved in dichloromethane
3. washThe solution was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified with silica gel flash column chromatography (eluent: chloroform)