反应详情

温度

25 °C

First, a toluene (1 L) solution of pyruvic acid (440 g, 5.0 mol), n-butanol (371 g, 5.0 mol) and p-toluenesulfonic acid monohydrate (2.5 g) was heated and refluxed for 16 hours while removing water under a nitrogen gas stream, whereby a first reaction solution was obtained. Next, the first reaction solution was cooled to room temperature (25° C.). Thereafter, toluene was removed under reduced pressure (40 mmHg) using an evaporator, and the residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.), whereby butyl pyruvate (505 g, yield 70%) was obtained.

1. temperaturerefluxed for 16 hours
2. customwhile removing water under a nitrogen gas stream, whereby a first reaction solution
3. customwas obtained
4. customThereafter, toluene was removed under reduced pressure (40 mmHg)
5. customan evaporator
6. distillationthe residue was purified by reduced pressure distillation (40 mmHg, 93 to 100° C.)