HCID 71295146, compound → HCID 68008520, compound

HRID 868819Notes

Reaction equation

HRID 868819 reaction equation
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([N+:13]([O-])=O)=[N:11][CH:12]=2)[CH2:3][CH2:2]1.[H][H]>O1CCCC1.[Pd]>[O:1]1[CH2:2][CH:3]=[C:4]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[N:11][CH:12]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 71295146HCID 71295146, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68008520HCID 68008520, compoundYield 92.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

174 mg of 5-(3,6-dihydro-2H-pyran-4-yl)-2-nitropyridine are hydrogenated using 100 mg of 5% Pd/C and hydrogen in 10 ml of tetrahydrofuran. The mixture is filtered off and evaporated in a rotary evaporator, giving 138 mg of 5-(3,6-dihydro-2H-pyran-4-yl)pyridin-2-ylamine crude product, which is reacted further above purification.

Workup

  1. filtrationThe mixture is filtered off
  2. customevaporated in a rotary evaporator

Sources & evidence

ORD record
ord-d88a68c2922446a8a39eeb55ac0194d8
Source dataset
uspto-grants-2015_03
Patent number
US08969335B2

Reaction notes

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