反应详情

温度

145 °C

A mixture of 2-methylbenzo[d]oxazole (3 g, 22.6 mmol) in DMF (3.2 g) and dimethyl acetamide (3.5 g, 29.3 mmol) was stirred under N2 at 145° C. overnight. Then the solution was poured into ice-water and extracted with EtOAc (100 mL×2). The organic phase was washed, dried and concentrated. The residue was purified by column chromatography to get the title compound (2.2 g). MS (ESI) m/z 134 (M+H+).

1. extractionextracted with EtOAc (100 mL×2)
2. washThe organic phase was washed
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by column chromatography