反应详情

A mixture of benzaldehyde (3 g, 28.3 mmol), 1-(isocyanomethylsulfonyl)-4-methylbenzene (5.5 g, 28.3 mmol) and K2CO3 (5.9 g, 42.5 mmol) in 60 mL methanol was refluxed for 2 h and then concentrated. 250 mL EtOAc was added and the mixture was washed with water and brine, dried, and concentrated to give 5-phenyl oxazole (3.4 g). MS (ESI) m/z 145 (M+H+).

1. temperaturewas refluxed for 2 h
2. concentrationconcentrated
3. addition250 mL EtOAc was added
4. washthe mixture was washed with water and brine
5. customdried
6. concentrationconcentrated