7-Methoxyquinoline-8-carboxylic acid → 7-Hydroxyquinoline-8-carboxylic acid

HRID 869016Notes

Reaction equation

HRID 869016 reaction equation
C[O:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1>Br>[OH:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 687745837-Methoxyquinoline-8-carboxylic acid

Product 1

HCID 1358815557-Hydroxyquinoline-8-carboxylic acid

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

The title compound of Step A (2.9 g, 14.1 mmol) in HBr (14 mL) was heated at 90° C. for 1 h. The mixture was then concentrated washed with PhCH3 and used without further purification in subsequent steps.

Workup

  1. concentrationThe mixture was then concentrated
  2. washwashed with PhCH3
  3. customused without further purification in subsequent steps

Sources & evidence

ORD record
ord-fd5a47708d0f43f8bb73ea41a9c0c9c6
Source dataset
uspto-grants-2015_03
Patent number
US08969352B2

Reaction notes

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