Lithium Chloride → HCID 178509968, compound
Reaction equation
I[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.C([Mg:14][Cl:15])(C)C.[Li+].[Cl-]>C1COCC1>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([Mg:14][Cl:15])=[CH:3][C:4]=1[F:10])#[N:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of 4-iodo-2-fluorobenzonitrile (2.5 g, 10.12 mmol) in 10.12 ml THF under argon, a solution of isopropylmagnesium chloride. LiCl in THF (10.12 ml, 13.16 mmol) was added at 0° C. The reaction mixture was stirred at this temperature for 5 min to afford the title compound, which was used immediately in the next step as a stock solution (˜0.5M in THF).
Sources & evidence
- ORD record
- ord-97e332776eee4adda06df08c52199f0f
- Source dataset
- uspto-grants-2015_03
- Patent number
- US08969341B2
Reaction notes
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