Hydrochloric Acid → HCID 136375768, compound

HRID 869238Notes

Reaction equation

HRID 869238 reaction equation
C([O:4][C:5]1[C:10]([C:11](=[O:13])[NH2:12])=[C:9]([NH:14][C:15]2[CH:16]=[N:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:8]=[C:7]([S:25][CH3:26])[N:6]=1)(=O)C.C(O)C.[OH-].[Na+].Cl>C1COCC1>[CH3:26][S:25][C:7]1[NH:6][C:5](=[O:4])[C:10]([C:11]([NH2:12])=[O:13])=[C:9]([NH:14][C:15]2[CH:16]=[N:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:8]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 66642837HCID 66642837, compound

Product 1

HCID 136375768HCID 136375768, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 5-carbamoyl-2-(methylsulfanyl)-6-(quinolin-3-ylamino)pyrimidin-4-yl acetate (Preparation Example 346) (0.71 g), ethanol (14 mL) and THF (14 mL) were added, and 1M aqueous sodium hydroxide (6 mL) was added and stirred at room temperature for 1 hour. Then, 1M hydrochloric acid (6 mL) was added, and the precipitated solid was collected by filtration and dried to give 2-(methylsulfanyl)-6-oxo-4-(quinolin-3-ylamino)-1,6-dihydropyrimidine-5-carboxamide (0.63 g).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-6469c1215e7d442185796655d64e2a65
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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