Hydrochloric Acid → HCID 66642852, compound

HRID 869244Notes

Reaction equation

HRID 869244 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][C:5]([NH:9]C(=O)OC(C)(C)C)([CH3:8])[CH2:4][CH2:3]1.C(O)C.[ClH:20]>C(OCC)(=O)C>[ClH:20].[ClH:20].[CH3:8][C:5]1([NH2:9])[CH2:6][CH2:7][CH:2]([NH2:1])[CH2:3][CH2:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20754832Carbamic acid, N-(4-amino-1-methylcyclohexyl)-, 1,1-dimethylethyl ester

Product 1

HCID 66642852HCID 66642852, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of tert-butyl (4-amino-1-methylcyclohexyl)carbamate (Preparation Example 399) (3.73 g) and ethanol (30 mL), 4M hydrogen chloride in ethyl acetate (30 mL) was added under ice cooling and stirred at room temperature for 20 hours. The precipitated solid was collected by filtration and washed with ethyl acetate to give 1-methylcyclohexane-1,4-diamine dihydrochloride (2.10 g) as a white solid.

Workup

  1. additionwas added under ice cooling
  2. filtrationThe precipitated solid was collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-a3defbda903c4b33adc2cbe920d52327
Source dataset
uspto-grants-2015_03
Patent number
US08969336B2

Reaction notes

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