反应详情

The compound obtained in Example 2-1 step (v) (0.5 g) was added to potassium carbonate (0.92 g) and 1,4-dibromobutane (0.85 ml) in dimethylformamide (5 ml), and the mixture was stirred at room temperature for 16 hours. To the reaction solution was added brine and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and concentrated to dryness. The residue was purified by flash column chromatography (ethyl acetate) to give the titled compound, as a white solid. Yield: 370 mg (70%).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with brine
3. concentrationconcentrated to dryness
4. customThe residue was purified by flash column chromatography (ethyl acetate)