HRID869345

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

HCID8028

Tetrahydrofuran

C4H8O

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(C)S(=O)(=O)c3cccc(CC(=O)OC)c3)c2n1

HCID11526476

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(C)S(=O)(=O)c3cccc(CC(=O)O)c3)c2n1

HCID11713143

未命名化合物

HCID21882825

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The compound obtained in Example 2-17 (100 mg) and lithium hydroxide (20 mg) were added to tetrahydrofuran (4 ml) and water (2 ml), followed by conducting a reaction by the same manner to Example 2-12, the titled compound was obtained as a white solid from diethyl ether/isohexane. Yield: 43 mg (64%); mp 171-172° C., MS APC+ve 507 (M+H).

WORKUP

后处理

customa reaction by the same manner to Example 2-12

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e92b6454575a4d8687db7031fbf15f08
来源数据集: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08969362B2
来源说明: uspto-grants-2015_03

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:36])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH3:35])[S:21]([C:24]1[CH:25]=[C:26]([CH2:30][C:31]([O:33]C)=[O:32])[CH:27]=[CH:28][CH:29]=1)(=[O:23])=[O:22].[OH-].[Li+].[O:39]1[CH2:43][CH2:42][CH2:41][CH2:40]1>O>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:36])[N:6]2[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH3:35])[S:21]([C:24]1[CH:25]=[C:26]([CH2:30][C:31]([OH:33])=[O:32])[CH:27]=[CH:28][CH:29]=1)(=[O:22])=[O:23].[CH2:40]([O:39][CH2:43][CH3:42])[CH3:41].[CH3:29][CH2:24][CH2:25][CH:26]([CH3:30])[CH3:27]