反应详情

By the same manner to Example 2-12, the compound obtained in Example 2-22 (70 mg) and lithium hydroxide (20 mg) were added to tetrahydrofuran (4 ml) and water (2 ml) and the mixture was stirred at room temperature for 24 hours. The reaction mixture was concentrated under reduced pressure and partitioned between 2M hydrochloric acid and ethyl acetate. The aqueous layer was extracted with ethyl acetate and the combined organic layer was dried and concentrated under reduced pressure to give the titled compound as a white solid. Yield: 23 mg (34%); MS APCI+ve 565 (M+H).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. custompartitioned between 2M hydrochloric acid and ethyl acetate
3. extractionThe aqueous layer was extracted with ethyl acetate
4. customthe combined organic layer was dried
5. concentrationconcentrated under reduced pressure