Sodium Hydroxide → HCID 86722237, compound

HRID 869388Notes

Reaction equation

HRID 869388 reaction equation
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Cl:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][C:22]([CH:25]=O)=[CH:23][N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+]>C1COCC1>[NH2:9][C:8]1[C:7]2[C:10]([Cl:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])/[CH:2]=[CH:25]/[C:22]1[S:21][C:20]([CH:17]([CH3:19])[CH3:18])=[N:24][CH:23]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 450838485-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI)HCID 86722235HCID 86722235, compound

Product 1

HCID 86722237HCID 86722237, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

7G (3 g, 12.5 mmol) was dissolved in THF (tetrahydrofuran, 30 mL). To the solution was added 2-isopropyl-thiazole-5-carbaldehyde (2.33 g, 15 mmol, 1.2 eq), followed by crushed NaOH powder (1 g, 25 mmol, 2 eq). The reaction mixture was stirred at room temperature for 10 min. The solution became dark and some solids formed. The mixture was poured into ice-water under stirring.

Workup

  1. customsome solids formed
  2. stirringunder stirring

Sources & evidence

ORD record
ord-271882d0b4f7420ea38dd17a9b13c444
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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