Hydrochloric Acid → HCID 86722249, compound

HRID 869404Notes

Reaction equation

HRID 869404 reaction equation
[Br:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10]C(C)=O)[CH:5]=[CH:4][C:3]=1[O:14][C:15]([CH3:17])=[O:16].CO.C([O-])([O-])=O.[K+].[K+].Cl>ClCCl>[C:15]([O:14][C:3]1[CH:4]=[CH:5][C:6]([OH:10])=[C:7]([C:8]#[N:9])[C:2]=1[Br:1])(=[O:16])[CH3:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 11430Potassium CarbonateHCID 86722248HCID 86722248, compound

Product 1

HCID 86722249HCID 86722249, compoundYield 62.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

12C (15 g, 0.05 mol) was added to MeOH (52 ml) and dichloromethane (52 mL). To the mixture was added K2CO3 (7 g, 0.05 mol) in batches at room temperature. The reaction mixture was stirred overnight at room temperture, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with dichloromethane, dried over anhydrous Na2SO4 and concentrated to give 12D (8 g, 62.1% yield).

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-079f798c7ac44463a7e558471894e8f8
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

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