Hydrochloric Acid → HCID 86722251, compound

HRID 869406Notes

Reaction equation

HRID 869406 reaction equation
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14]C(C)=O)=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].C([O-])([O-])=O.[K+].[K+].Cl>CO.O>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([Br:18])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 86722250HCID 86722250, compound

Product 1

HCID 86722251HCID 86722251, compoundYield 98.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a mixture of 12E (6.8 g, 0.021 mol) in MeOH (40 mL) and water (20 mL) was added K2CO3 (4.5 g, 0.032 mol) in batches at room temperature. The reaction mixture was stirred at room temperature overnight, then neutralized with diluted hydrochloric acid to pH=6˜7, extracted with ethyl acetate, dried and concentrated to give 12F (5.6 g, 95.1% yield).

Workup

  1. extractionextracted with ethyl acetate
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-70fdf9670d164dcb92cb3c74ae0e0846
Source dataset
uspto-grants-2015_03
Patent number
US08969373B2

Reaction notes

Loading…