反应详情

温度

65 °C

Method B (DMAP salt): A suspension of ethyl 3-{[3-(3-methylquinoxalin-2-yl)-1H-pyrazol-5-yl]amino}-3-oxopropanoate (1.00 g, 2.95 mmol) and 4-dimethylaminopyridine (DMAP) (1.08 g, 8.84 mmol) in water (7 mL), tetrahydrofuan (7 mL), and methanol (7 mL) was heated at 65° C. for 4 h. After being cooled to ambient temperature, the reaction mixture was diluted with water and ethyl acetate. The aqueous layer was collected and concentrated in vacuo. The residue was triturated with ether acetate to give 2-(3-methylquinoxalin-2-yl)pyrazolo[1,5-a]pyrimidine-5,7-diol DMAP salt. MS (APCI): m/z 294 (M+H).

1. temperatureAfter being cooled to ambient temperature
2. customThe aqueous layer was collected
3. concentrationconcentrated in vacuo
4. customThe residue was triturated with ether acetate